Aim: The present study was done to find out the association between the periodontal status and oral mucosal lesions among smokeless tobacco users in small scale industries of Chennai. Settings and Design: cross sectional analytical study. Methods and Materials: A stratified random sampling of 750 small scale industrial workers from the five strata were examined to assess the prevalence of periodontal disease and oral mucosal lesions associated with the use of smokeless tobacco. Periodontal status was assessed by Community periodontal index (CPI and LA), while smokeless tobacco-induced oral mucosal lesions were graded using a method developed by Greer and Poulson. Statistical analysis used: Spearman rank correlation analysis was applied to assess the correlation between smokeless tobacco usage, periodontal disease and oral mucosal lesions in small scale industrial study subjects. Results: There existed a positive correlation between the periodontal disease status along with loss of attachment and the daily frequency of the tobacco usage habit. Smokeless tobacco induced lesions were mostly observed among subjects who indulged in combination of all the Smokeless tobacco use habits, which showed a highly significant association. Conclusions: The present study showed a positive correlation between prevalence of periodontal disease and oral mucosal lesions among smokeless tobacco users in small scale industries. The results of this study can be implied in planning health education, oral health programs and free services for tobacco cessation and dental treatment, especially to the industrial sector.