Background: Protecting the quality of life is an important factor in patients with chronic disease because of increasing their survival rate. This study aims to investigate the quality of life (QOL) of Heart Failure patients and specify the most important related factors to it. Materials and Methods: In a cross-sectional study a sample of 80 patients in Kermanshah’s hospitals was selected non-randomly. The QOL was measured by WHOQOL-BREF- WHO questionnaire- and the data were finally analyzed in the light of study objectives with SPSS -16. Results: The average age of the patients was 65.5±14.3 years. Female and male constituted 48.8 (39 patients) and 51.2 (41 patients) percent, respectively. The patients obtained average high score in social relationship domain and low score in physical health domain. There is a significant relationship between habitat place (P=0.05), number of hospitalization) P=0.001) and disease stage (p<0.001) with their quality of life. Conclusion: The Heart Failure patients have an undesirable conditions in domain of physical health. Patients in advanced stage of disease have a lowest level of quality of life and need more cares.