Objective: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis.

Settings: Hepatology department, Ain Shams University Hospital

Subjects: Male and female patients with Liver cirrhosis

Measurements and main results: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh and positive correlation was noticed between GFRcr and GFRcys and significant positive correlation was noticed between Cystatin c and RRI and this is support our recommendation of using of serum cystatin c and renal resistive index for evaluation of renal status in liver cirrhotic patients.

Conclusion: Cystatin C can be used as reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.