Background: Statin therapy is a cornerstone of secondary prevention after percutaneous coronary intervention (PCI). Beyond lipid lowering, statins provide anti-inflammatory, plaque-stabilizing, and endothelial protective effects that may improve post-PCI outcomes.

Objective: To review the impact of statin therapy on clinical outcomes after PCI, including mortality, myocardial infarction, restenosis, stent thrombosis, and repeat revascularization.

Methods: This narrative review summarizes clinical evidence from randomized trials, registries, meta-analyses, and contemporary cardiovascular prevention guidelines.

Results: High-intensity statin therapy after PCI is associated with reduced major adverse cardiovascular events, lower recurrent myocardial infarction, improved plaque stabilization, and better long-term survival. Early statin loading before PCI may reduce periprocedural myocardial injury, particularly in acute coronary syndrome patients.

Conclusion: Statin therapy should be initiated early and continued long-term after PCI. High-intensity statins are preferred unless contraindicated, with LDL-C targets guiding dose escalation and addition of non-statin agents.